Publications

2026

36. S Feng, C Adamson, C Li, EWL Ng, Y Qiao*. Intracellular structural modifications of natural peptidoglycan fragments preceding NOD2 signaling in mammalian cells. Proc Natl Acad Sci U S A. 2026 Jul 14;123(28):e2535544123. doi: 10.1073/pnas.2535544123.

35. Y Zhao, C Adamson, C Li, Y Liang, EWL Ng, Y Qiao*. Fluorescent peptidoglycan probes for fluorescence polarization displacement assays to investigate ligand recognition by human peptidoglycan recognition protein 1. ChemBioChem. 2026 Mar 13;27(5):e202500792. doi: 10.1002/cbic.202500792.

34. Y Liang, C Adamson, C Li, EWL Ng, Y Li, Y Qiao*. Discovery of bioactive peptidoglycan fragments from Lactobacillaceae that confer intestinal protection in hosts. Cell Chem Biol. 2026 Feb 19;33(2):198-212.e11. doi: 10.1016/j.chembiol.2026.01.005.

33. Q Li, XL Zhang, R Liu, P Wang, H Cao, AWR Ng, Y Qiao, H Ding*, XW Liu*, M Li*. A synthetic Antrodia cinnamomea galactomannan library by frameshift unveils a potent immunoregulatory octasaccharide domain. Sci Adv. 2026 Jan 30;12(5):eaec5309. doi: 10.1126/sciadv.aec5309.

32. S Lee, Y Lee, HS Lee, J Yu, K Kim, TY Kim, SH Lee, Y Qiao, S Kim, MN Kweon*. Peptidoglycan from Bifidobacterium adolescentis enhances IL-10 production in regulatory B cells to alleviate gut inflammation. Gut Microbes. 2026; 18(1): 2611603. doi: 10.1080/19490976.2025.2611603.

2025

31. B Li, Z Zhang, DP Situmorang, QN Lim, Y Liang, Y Qiao, TP Loh*. Alkynyl Aldehyde: A Thiol-Specific Reagent Carrying a Versatile Formyl Group. CCS Chemistry, 2025, 8, 781–792 doi: 10.31635/ccschem.025.202506216.

30. KL Chew, Y Qiao, P Lye, J Cruz Cabang, NABA Bakar, KX Tan, J Teo*. Whole-genome analysis of NDM-producing Providencia hangzhouensis associated with recurrent bacteraemia with rapid development of aztreonam-avibactam resistance. Emerg Microbes Infect. 2025 Dec;14(1):2539193. doi: 10.1080/22221751.2025.2539193.

29. C Adamson, EWL Ng, AWR Ng, S Feng, Y Qiao.* Chemoselective Modification of Reducing 2-Acetamido Sugars Enables Facile Functionalization of Diverse Peptidoglycan Fragments Derived from the Gut Microbiota. JACS Au. 2025 Aug 21;5(9):4449-4458. doi: 10.1021/jacsau.5c00790.

28. L Li, C Adamson, EWL Ng, Y Qiao.* Candida albicans Ssy1 is the extracellular sensor of gut microbiota-derived peptidoglycan fragments mediating invasive hyphal growth in the host. Nat Commun. 2025 Jul 22;16(1):6737. doi: 10.1038/s41467-025-62097-y.

Behind the paper story

Blogpost from Science@NTU

27. C Li, C Adamson, AWR Ng, Y Liang, Z Hong, JT Loh, SK Ng, JMC Kwan, S Feng, EWL Ng, NS Kumar, C Ruedl, S Wong, KP Lam, Y Qiao*. Gut microbiota-derived GlcNAc-MurNAc is a TLR4 agonist that protects the host gut. Nat Commun. 2025 Jul 1;16(1):5577. doi: 10.1038/s41467-025-60678-5.

Behind the pper story

Blogpost from Science@NTU

Highlight by BioArt

26. JMC Kwan, F Shi, EWL Ng, Y Qiao*. Biochemical characterization of Bifidobacterium bifidum peptidoglycan d,l-endopeptidase BbMep that generates NOD2 ligands. RSC Chem Biol. 2025. doi: 10.1039/D5CB00086F

25. L Li, Y Qiao*. Opportunities in exploring chemical biology tools for better strategies against Candida albicans. Curr. Opin. Chem. Biol. 2025, Jun;86:102595. doi: 10.1016/j.cbpa.2025.102595.

24. Y Liang, C Adamson, S Feng, Y Qiao*. Exploring the Impact of Amidation Status in Meso-Diaminopimelic-Acid-Containing Disaccharide Peptidoglycan Fragments on Host Innate Immune Activation. ACS Chem Biol. 2025 Jan 17;20(1):69-76. doi: 10.1021/acschembio.4c00700.

2024

23. S. Shin, J Yu, H Tae, Y Zhao, D Jiang, Y Qiao, W Kim, NJ Cho. Exploring the Membrane-Active Interactions of Antimicrobial Long-Chain Fatty Acids Using a Supported Lipid Bilayer Model for Gram-Positive Bacterial Membranes. ACS Appl Mater Interfaces. 2024 Oct 23;16(42):56705-56717. doi: 10.1021/acsami.4c11158.

22. JL Fong, V Ong Eng Yong, C Yeo, C Adamson, L Li, D Zhang, Y Qiao*. Biochemical Characterization of Recombinant Enterococcus faecalis EntV Peptide to Elucidate Its Antihyphal and Antifungal Mechanisms against Candida albicans. ACS Infect Dis. 2024 Aug 13. doi: 10.1021/acsinfecdis.4c00515.

21. XL Zhang, G Bati, C Li, A Guo, C Yeo, H Ding, K Pal, Y Xu, Y Qiao*, XW Liu* . GlcNAc-1,6-anhydro-MurNAc moiety affords unusual glycosyl acceptor that terminates peptidoglycan elongation. J. Am. Chem. Soc, 2024. 146(11):7400-7407. doi: 10.1021/jacs.3c12526.

20. C. Adamson, Y. Liang , S. Feng, AWR. Ng, Y. Qiao*. A closer look at ligand specificity for cellular activation of NOD2 with synthetic muramyl dipeptide analogues. ChemComm. 2024. 60, 2212-2215. doi: 10.1039/D3CC05807G

19. JMC. Kwan, Y. Liang, EWL. Ng, E. Sviriaeva, C. Li, Y. Zhao, XL. Zhang, XW. Liu , S. Wong, Y. Qiao*. In silico MS/MS prediction for peptidoglycan profiling uncovers novel anti-inflammatory peptidoglycan fragments of the gut microbiota. Chem. Sci. 2024, 15, 1846-1859, doi: 10.1039/D3SC05819K

2023

18. AWR. Ng, L. Li, EWL. Ng, C. Li, Y. Qiao*. Molecular docking reveals critical residues in Candida albicans Cyr1 for peptidoglycan recognition and hyphal growth . ACS Infec Dis. 2023, 9(7):1362-1371. doi: 10.1021/acsinfecdis.3c00115.

17. Y. Liang, Y. Zhao, JMC. Kwan, Y. Wang, Y. Qiao*. Escherichia coli has robust regulatory mechanisms against elevated peptidoglycan cleavage by lytic transglycosylases. J. Biol. Chem. 2023 , 299(4):104615. doi: 10.1016/j.jbc.2023.104615.

16. JMC. Kwan, Y. Qiao*. Mechanistic insights into the activitves of major families of enzymes in bacterial peptidoglycan assembly and breakdown. ChemBioChem, 2023 Jan 30:e202200693. doi: 10.1002/cbic.202200693. (selected as a VIP paper)

2022

15. L. Li, AWR. Ng, C. Adamson, H. Hayashi, C. Li, H. Lim, Y. Qiao*. Chemoenzymatic Probes Reveal Peptidoglycan Recognition and Uptake Mechanisms in Candida albicans. ACS Chem Biol. 2022 Sep 16;17(9):2538-2550. doi: 10.1021/acschembio.2c00468.

14. C. Li, Y. Liang, Y. Qiao*. Messengers of the gut: gut-microbiota derived metabolites on host regulation. Front Microbiol. 2022 Apr 22;13:863407. doi: 10.3389/fmicb.2022.863407.

2021

13. C.T. Tan, X. Xu, Y. Qiao*, Y. Wang*. A peptidoglycan storm caused by β-lactam antibiotic’s action on host microbiota drives Candida albicans infection. Nat Commun. 2021 May 7;12(1):2560. doi: 10.1038/s41467-021-22845-2.

2020

12. Y. Qiao*, H. Hayashi, SC. Teo. Chemical Toolbox to Decode the Microbiota Lexicon. Chem Asian J. 2020, 15(14):2117-2128. https://doi.org/ 10.1002/asia.202000541. (For the special collection of 50th anniversary of SNIC)

Pre-NTU

11. ZX. Huang, JH. Wang, XL. Xu, HS. Wang, Y. Qiao, WC. Chu, SL. Xu, L. Chai, F. Cottier, N. Pavelka, M. Oosting, LAB. Joosten, M. Netea, CYL. Ng, KP. Leong, P. Kundu, KP. Lam, S. Petterson, Y. Wang. Antibody neutralization of microbiota-derived circulating peptidoglycan dampens inflammation and ameliorates autoimmunity. Nat. Microbiol. 2019, 4, 766–773.

10. MM. Zhang‡, Y. Qiao‡, EL. Ang, H. Zhao. Using Natural Products for Drug Discovery: the Impact of the Genomic Era. Expert Opin Drug Discov. 2017, 12(5): 475-487. (‡ equal contribution)

9. V. Srisuknimit‡, Y. Qiao‡, K. Schaefer, D. Kahne, S. Walker. Peptidoglycan Cross-Linking Preferences of Staphylococcus aureus Penicillin-Binding Proteins Have Implications for Treating MRSA Infections. J. Am. Chem. Soc. 2017, 139(29): 9791-9794. (‡ equal contribution)

8. Y. Qiao‡, V. Srisuknimit‡, F. Rubino, K. Schaefer, N. Ruiz, S. Walker, D. Kahne. Lipid II Overproduction Allows Direct Assay of Transpeptidase Inhibition by Beta-lactams. Nat. Chem. Biol. 2017, 13(7): 793-798. (‡ equal contribution)

7. K. Schaefer, L. Matano, Y. Qiao, D. Kahne, S. Walker. In Vitro Reconstitution Demonstrates the Cell Wall Ligase Activity of LCP proteins. Nat. Chem. Biol. 2017, 13 (4): 396-401.

6. W. Lee, K. Schaefer, Y. Qiao, V. Srisuknimit, H. Steinmetz, R. Müller, D. Kahne, S. Walker. The Mechanism of Action of Lysobactin. J. Am. Chem. Soc. 2015, 138(1): 100-3.

5. Y. Qiao, MD. Lebar, K. Schirner, K. Schaefer, H. Tsukamoto, D. Kahne, S. Walker. Detection of Lipid-linked Peptidoglycan Precursors by Exploiting an Unexpected Transpeptidase Reaction. J. Am. Chem. Soc. 2014, 136(42): 14678-81.

4. Y. Rebets, T. Lupoli, Y. Qiao, K. Schirner, R. Villet, D. Hooper, D. Kahne, S. Walker. Moenomycin Resistance Mutations in Staphylococcus aureus Reduce Peptidoglycan Chain Length and Cause Aberrant Cell Division. ACS Chem Biol 2014, 9(2): 459-673.

3. K. Fukushima, JPK. Tan, PA. Korevar, Y. Y. Yang, J. Pitera, A. Nelson, H. Maune, DJ. Coady, JE. Frommer, AC. Engler, Y. Huang, K. Xu, Z. Ji, Y. Qiao, W. Fan, L. Li, N. Wiradharma, EW. Meijer, JL. Hedrick. Broad Spectrum Antimicrobial Supramolecular Assemblies with Distinctive Size and Shape. ACS Nano 2012, 6, 9191-9199.

2. Y. Qiao, C. Yang, DJ. Coady, ZY. Ong, JL. Hedrick, Y. Y. Yang. Highly Dynamic Biodegradable Micelles Capable of Lysing Gram-positive and Gram-negative Bacterial Membrane. Biomaterials 2012, 33, 1146-1153

1. Y. Qiao, S. Kumar, W. P. Malachowski. Enatioselective Synthesis of Bicarbocyclic Structures with All Carbon Quaternary Stereocenters through Sequential Cross Metathesis and Intramolecular Rauhut-Currier Reaction. Tet. Lett. 2010, 51, 2636-2638

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