Embedded Files
Post-2020
Post-2020
25. Li CY, Adamson C, Ng AWR, Liang YQ, Hong ZB, Loh JT, Ng SK, Kwan JMC, Feng SL, Ng EWL, Kumar NS, Ruedl C, Wong S, Lam KP, Qiao Y*. Gut microbiota-derived GlcNAc-MurNAc is a TLR4 agonist that protects the host gut.
24. Liang Y, Adamson C, Feng S, Qiao Y. Exploring the Impact of Amidation Status in Meso-Diaminopimelic-Acid-Containing Disaccharide Peptidoglycan Fragments on Host Innate Immune Activation. ACS Chem Biol. 2025 Jan 17;20(1):69-76. doi: 10.1021/acschembio.4c00700.
23. Shin S, Yu J, Tae H, Zhao Y, Jiang D, Qiao Y, Kim W, Cho NJ. Exploring the Membrane-Active Interactions of Antimicrobial Long-Chain Fatty Acids Using a Supported Lipid Bilayer Model for Gram-Positive Bacterial Membranes. ACS Appl Mater Interfaces. 2024 Oct 23;16(42):56705-56717. doi: 10.1021/acsami.4c11158.
22. JL Fong, V Ong Eng Yong, C Yeo, C Adamson, L Li, D Zhang, Y Qiao*. Biochemical Characterization of Recombinant Enterococcus faecalis EntV Peptide to Elucidate Its Antihyphal and Antifungal Mechanisms against Candida albicans. ACS Infect Dis. 2024 Aug 13. doi: 10.1021/acsinfecdis.4c00515.
21. XL Zhang, G Bati, C Li, A Guo, C Yeo, H Ding, K Pal, Y Xu, Y Qiao*, XW Liu* . GlcNAc-1,6-anhydro-MurNAc moiety affords unusual glycosyl acceptor that terminates peptidoglycan elongation. J. Am. Chem. Soc, 2024. 146(11):7400-7407. doi: 10.1021/jacs.3c12526.
20. C. Adamson, Y. Liang , S. Feng, AWR. Ng, Y. Qiao.* A closer look at ligand specificity for cellular activation of NOD2 with synthetic muramyl dipeptide analogues. ChemComm. 2024. 60, 2212-2215. doi: 10.1039/D3CC05807G
19. JMC. Kwan, Y. Liang, EWL. Ng, E. Sviriaeva, C. Li, Y. Zhao, XL. Zhang, XW. Liu , S. Wong, Y. Qiao.* In silico MS/MS prediction for peptidoglycan profiling uncovers novel anti-inflammatory peptidoglycan fragments of the gut microbiota. Chem. Sci. 2024, 15, 1846-1859, doi: 10.1039/D3SC05819K
(BioRxiv 2023, doi: https://doi.org/10.1101/2023.10.08.561446 )
18. AWR. Ng, L. Li, EWL. Ng, C. Li, Y. Qiao*. Molecular docking reveals critical residues in Candida albicans Cyr1 for peptidoglycan recognition and hyphal growth . ACS Infec Dis. 2023, 9(7):1362-1371. doi: 10.1021/acsinfecdis.3c00115.
17. Y. Liang, Y. Zhao, JMC. Kwan, Y. Wang, Y. Qiao*. Escherichia coli has robust regulatory mechanisms against elevated peptidoglycan cleavage by lytic transglycosylases. J. Biol. Chem. 2023 , 299(4):104615. doi: 10.1016/j.jbc.2023.104615.
16. JMC. Kwan, Y. Qiao* Mechanistic insights into the activitves of major families of enzymes in bacterial peptidoglycan assembly and breakdown. ChemBioChem, 2023 Jan 30:e202200693. doi: 10.1002/cbic.202200693. (selected as a VIP paper)
15. L. Li, AWR. Ng, C. Adamson, H. Hayashi, C. Li, H. Lim, Y. Qiao* Chemoenzymatic Probes Reveal Peptidoglycan Recognition and Uptake Mechanisms in Candida albicans. ACS Chem Biol. 2022. 17, 9, 2538-2550. https://doi.org/10.1021/acschembio.2c00468
14. C. Li, Y. Liang, Y. Qiao* Messengers of the gut: gut-microbiota derived metabolites on host regulation. Front. Microbiol. 13, 2022.13:863407 https://doi.org/10.3389/fmicb.2022.863407
13. C.T. Tan, X. Xu, Y. Qiao*, Y. Wang*. A peptidoglycan storm caused by β-lactam antibiotic’s action on host microbiota drives Candida albicans infection. Nat Commun 2021, 12, 2560 . https://doi.org/10.1038/s41467-021-22845-2
12. Y. Qiao*, H. Hayashi, SC. Teo. Chemical Toolbox to Decode the Microbiota Lexicon. Chem Asian J. 2020, 15(14):2117-2128. https://doi.org/ 10.1002/asia.202000541. (For the special collection of 50th anniversary of SNIC)
Pre-NTU:
Pre-NTU:
11. ZX. Huang, JH. Wang, XL. Xu, HS. Wang, Y. Qiao, WC. Chu, SL. Xu, L. Chai, F. Cottier, N. Pavelka, M. Oosting, LAB. Joosten, M. Netea, CYL. Ng, KP. Leong, P. Kundu, KP. Lam, S. Petterson, Y. Wang. Antibody neutralization of microbiota-derived circulating peptidoglycan dampens inflammation and ameliorates autoimmunity. Nat. Microbiol. 2019, 4, 766–773.
10. MM. Zhang‡, Y. Qiao‡, EL. Ang, H. Zhao. Using Natural Products for Drug Discovery: the Impact of the Genomic Era. Expert Opin Drug Discov. 2017, 12(5): 475-487.
9. V. Srisuknimit‡, Y. Qiao‡, K. Schaefer, D. Kahne, S. Walker. Peptidoglycan Cross-Linking Preferences of Staphylococcus aureus Penicillin-Binding Proteins Have Implications for Treating MRSA Infections. J. Am. Chem. Soc. 2017, 139(29): 9791-9794. (‡ equal contribution)
8. Y. Qiao‡, V. Srisuknimit‡, F. Rubino, K. Schaefer, N. Ruiz, S. Walker, D. Kahne. Lipid II Overproduction Allows Direct Assay of Transpeptidase Inhibition by Beta-lactams. Nat. Chem. Biol. 2017, 13(7): 793-798. (‡ equal contribution)
7. K. Schaefer, L. Matano, Y. Qiao, D. Kahne, S. Walker. In Vitro Reconstitution Demonstrates the Cell Wall Ligase Activity of LCP proteins. Nat. Chem. Biol. 2017, 13 (4): 396-401.
6. W. Lee, K. Schaefer, Y. Qiao, V. Srisuknimit, H. Steinmetz, R. Müller, D. Kahne, S. Walker. The Mechanism of Action of Lysobactin. J. Am. Chem. Soc. 2015, 138(1): 100-3.
5. Y. Qiao, MD. Lebar, K. Schirner, K. Schaefer, H. Tsukamoto, D. Kahne, S. Walker. Detection of Lipid-linked Peptidoglycan Precursors by Exploiting an Unexpected Transpeptidase Reaction. J. Am. Chem. Soc. 2014, 136(42): 14678-81.
4. Y. Rebets, T. Lupoli, Y. Qiao, K. Schirner, R. Villet, D. Hooper, D. Kahne, S. Walker. Moenomycin Resistance Mutations in Staphylococcus aureus Reduce Peptidoglycan Chain Length and Cause Aberrant Cell Division. ACS Chem Biol 2014, 9(2): 459-673.
3. K. Fukushima, JPK. Tan, PA. Korevar, Y. Y. Yang, J. Pitera, A. Nelson, H. Maune, DJ. Coady, JE. Frommer, AC. Engler, Y. Huang, K. Xu, Z. Ji, Y. Qiao, W. Fan, L. Li, N. Wiradharma, EW. Meijer, JL. Hedrick. Broad Spectrum Antimicrobial Supramolecular Assemblies with Distinctive Size and Shape. ACS Nano 2012, 6, 9191-9199.
2. Y. Qiao, C. Yang, DJ. Coady, ZY. Ong, JL. Hedrick, Y. Y. Yang. Highly Dynamic Biodegradable Micelles Capable of Lysing Gram-positive and Gram-negative Bacterial Membrane. Biomaterials 2012, 33, 1146-1153
1. Y. Qiao, S. Kumar, W. P. Malachowski. Enatioselective Synthesis of Bicarbocyclic Structures with All Carbon Quaternary Stereocenters through Sequential Cross Metathesis and Intramolecular Rauhut-Currier Reaction. Tet. Lett. 2010, 51, 2636-2638
Patents:
Patents:
1. C. Gampe, D. Kahne, S. Walker, Y. Qiao, S. East, A. Parkes, M. Southey, J. Hunter, M. Whittaker, A. Arthuis. Entitled: Inhibitors of Bacterial Glycosyl Transferses. International Patent No. PCT/US2016/034587
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